Journal article
TDP6, a brain-derived neurotrophic factor-based trkB peptide mimetic, promotes oligodendrocyte myelination
AW Wong, L Giuffrida, R Wood, H Peckham, D Gonsalvez, SS Murray, RA Hughes, J Xiao
Molecular and Cellular Neuroscience | Published : 2014
Abstract
Brain-derived neurotrophic factor (BDNF) plays critical roles in the development and maintenance of the central (CNS) and peripheral nervous systems (PNS). BDNF exerts its biological effects via tropomyosin-related kinase B (TrkB) and the p75 neurotrophin receptor (p75NTR). We have recently identified that BDNF promotes CNS myelination via oligodendroglial TrkB receptors. In order to selectively target TrkB to promote CNS myelination, we have used a putative TrkB agonist, a small multicyclic peptide (tricyclic dimeric peptide 6, TDP6) previously described by us that structurally mimics a region of BDNF that binds TrkB. We confirmed that TDP6 acts as a TrkB agonist as it provoked autophosphor..
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Awarded by Multiple Sclerosis Research Australia
Funding Acknowledgements
We would like to thank Prof. Trevor Kilpatrick for helpful discussions and comments on this manuscript during preparation. This work was supported by the Australian National Health and Medical Research Council project grant(#APP1058647), Multiple Sclerosis Research Australia Project Seed Fund (#12070), the University of Melbourne Research Grant Support Scheme and Melbourne Research CI Fellowship. We would like to acknowledge the Operational Infrastructure Scheme of the Department of Innovation, Industry and Regional Development, Victoria, Australia. The authors declare that they have no financial conflicts of interest regarding this research.